Acesulfame Potassium

Acesulfame Potassium

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Acesulfame potassium occurs as a colorless to white-colored, odorless, crystalline powder with an intensely sweet taste.

Nonproprietary Names

  • BP: Acesulfame Potassium
  • PhEur: Acesulfame Potassium
  • USP-NF: Acesulfame Potassium
Acesulfame Potassium

Synonyms Acesulfame K; ace K; acesulfamum kalicum; E950; 6-methyl-3,4- dihydro-1,2,3-oxathiazin-4(3H)-one-2,2-dioxide potassium salt; potassium 6-methyl-2,2-dioxo-oxathiazin-4-olate; Sunett; Sweet One.

Chemical Name and CAS Registry Number: 6-Methyl-1,2,3-oxathiazin-4(3H)-one-2,2-dioxide potassium salt [55589-62-3]

Empirical Formula and Molecular Weight

  • C4H4KNO4S 201.24

Functional Category

  • Sweetening agent.

Applications in Pharmaceutical Formulation or Technology

Acesulfame potassium is used as an intense sweetening agent in cosmetics, foods, beverage products, table-top sweeteners, vitamin and pharmaceutical preparations, including powder mixes, tablets, and liquid products. It is widely used as a sugar substitute in compounded formulations, and as a toothpaste sweetener.

The approximate sweetening power is 180–200 times that of sucrose, similar to aspartame, about one-third as sweet as sucralose, one-half as sweet as sodium saccharin, and about 4-5 times sweeter than sodium cyclamate. It enhances flavor systems and can be used to mask some unpleasant taste character istics.


Typical Properties

  • Acidity/alkalinity pH = 5.5–7.5 (1% w/v aqueous solution)
  • Bonding index 0.007
  • Brittle fracture index 0.08
  • Density (bulk) 1.04 g/cm3
  • Density (tapped) 1.28 g/cm3
  • Elastic modulus 4000MPa
  • Flowability 19% (Carr compressibility index)
  • Melting point 2508C

Method of Manufacture

Acesulfame potassium is synthesized from acetoacetic acid tertbutyl ester and fluorosulfonyl isocyanate. The resulting compound is transformed to fluorosulfonyl acetoacetic acid amide, which is then cyclized in the presence of potassium hydroxide to form the oxathiazinone dioxide ring system. Because of the strong acidity of this compound, the potassium salt is produced directly.

An alternative synthesis route for acesulfame potassium starts with the reaction between diketene and amidosulfonic acid. In the presence of dehydrating agents, and after neutralization with potassium hydroxide, acesulfame potassium is formed.


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