Contents

ACTION TABLETS

Each tablets contains; Aspirin BP 600mg, Paracetamol BP 300mg and Caffeine anhydrous BP 50mg.

Aspirin: Aspirin has an analgesic, anti-inflammatory and anti-pyretic actions. Aspirin acts by inhibiting the enzyme cyclo-oxygenase, which results in the inhibition of biosynthesis of prostaglandin. Prostaglandins are associated with development of pain that accompanies injury or inflammation. Enhanced production of prostaglandin is a common feature in fever. Aspirin also inhibits platelet aggregation.

Paracetamol: Paracetamol is an effective antipyretic and analgesic. It produces antipyresis by acting on the hypothalamic heat regulating center and analgesia by elevating the pain threshold.

Caffeine: Caffeine in lower doses stimulates the CNS and this imparts a synergistic effect to the Aspirin-Paracetamol combination.

Indications

For relief of pain due to headache, colds and flu, muscular aches, menstrual discomfort, toothache and sinusitis

Dosage

Adults: One tablet four times a day up to a maximum of six tablets daily.

Side effects

Transient gastro-intestinal tract effects includes stomach pains, heartburn and nausea. This can be avoided by taking the medicine after meals or with a glass of milk.

Contraindications

In patients with haemophilia or those with an intolerance to Aspirin, paracetamol or caffeine.

Precautions

Not to be taken when on anticoagulant drugs. Children under 12 years should not use this medicine as Reye syndrome, which is associated with the use of aspirin in children may occur. Not to be taken by those allergic to aspirin or have asthma, or recurrent ulcers. Should be given with care to patients with impaired kidney or liver function.

Warnings

Do not exceed the stated doses.

Overdosage

Over dosages may cause dizziness, tinnitus, sweating, nausea, mental confusion, hyperventilation, ketosis or coma.

Treatment of overdosage

For mild intoxication emptying the stomach by emesiis or aspiration or gastric lavage. Prompt administration of 50g activated charcoal and ½ liter of iced mannitol reduces absorption. In severe intoxication the risk of severe liver damage can be significantly reduced by the administration of methionine 2.5g by mouth every four hours until 10g has been given or IV 20% N-acetylcysteine should be administered.

ACTION TABLETS

ACTION TABLETS