Adrenaline (Epinephrine)

Adrenaline (Epinephrine)

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Adrenalin® 1 mg/mL (1:1000) epinephrine injection, 1 mL solution in a 3 mL single-use vial. Adrenaline (Epinephrine) belongs to a group of medicines used for the treatment of serious shock produced by a severe allergic (hypersensitive) reaction or collapse.

Anaphylaxis

Emergency treatment of allergic reactions (Type I), including anaphylaxis, which may result from allergic reactions to insect stings, biting insects, foods, drugs, sera, diagnostic testing substances and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis. 

The signs and symptoms associated with anaphylaxis include hypotension, airway swelling, laryngospasm, bronchospasm, urticaria, pruritus, angioedema, swelling of the eyelids, lips, and tongue, vomiting, diarrhea and abdominal cramps. Induction and Maintenance of Mydriasis during Intraocular Surgery

Pregnancy, breast-feeding and fertility

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine. Adrenaline Injection should only be used during pregnancy and breast-feed ing if considered essential by your doctor.

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Driving and using machines

You should not drive or use machinery if you are affected by the administration of Adrenaline Injection.

Dosage and administration

Adults and Children 30 kg (66 lbs) or more: 0.3 to 0.5 mg (0.3 to 0.5 mL) of undiluted Adrenalin administered intramuscularly or subcutaneously in the anterolateral aspect of the thigh, up to a maximum of 0.5 mg (0.5 mL) per injection, repeated every 5 to 10 minutes as necessary. Monitor clinically for reaction severity and cardiac effects.

Children less than 30 kg (66 lbs): 0.01 mg/kg (0.01 mL/kg) of undiluted Adrenalin administered intramuscularly or subcutaneously in the anterolateral aspect of the thigh, up to a maximum of 0.3 mg (0.3 mL), repeated every 5 to 10 minutes as necessary. Monitor clinically for reaction severity and cardiac effects.

Induction and Maintenance of Mydriasis during Intraocular Surgery

Adrenalin® must be diluted prior to intraocular use. Dilute 1 mL of Adrenalin® 1 mg/mL (1:1000) in 100 to 1000 mL of an ophthalmic irrigation fluid to create an epinephrine concentration of 1:100,000 to 1:1,000,000 (10 mcg/mL to 1 mcg/mL). Use the irrigating solution as needed for the surgical procedure. After dilution in an ophthalmic irrigating fluid, Adrenalin® may also be injected intracamerally as a bolus dose of 0.1 mL at a dilution of 1:100,000 to 1:400,000 (10 mcg/mL to 2.5 mcg/mL).

Possible side effects

Like all medicines Adrenaline Injection can cause side effects, although not everybody gets them. If you experience any of these following side effects, stop taking this medicine and report to a doctor immediately: • Allergic reactions although serious allergic reactions are rare • Any sudden wheeziness, difficulty in breathing, swelling of the eyelids, face or lips, rash or itching (especially affecting your whole body).



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