Artemether 20mg & Lumefantrine 120mg

Artemether 20mg & Lumefantrine 120mg

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Artemether 20mg & Lumefantrine 120mg

Artemether 20mg & Lumefantrine 120mg tablets is a combination medicine, which contains two active ingredients belonging to two different chemical groups: sesquiterpene lactone and aryl aminoalcohol. It is used to treat certain types of malaria infection in adults, children and infants of 5kg and above. It is a fixed dose combination of two drugs i.e. Artemether and Lumefantrine

This is a medicine for fever due to malaria. Malaria is a curable disease, which is caused by the bite of female anopheles mosquitoes that carry the malaria parasites. The earlier the malaria is treated with the correct medicine, the better.

Your doctor will have carried out a blood test and form the results of the blood test; your doctor has found that you have contracted a malaria infection due to Plasmodium falciparum (a particular type of malaria). Your doctor has, therefore, prescribed Artemether 20mg & Lumefantrine 120mg tablets to treat malaria infection.

Artemether 20mg & Lumefantrine 120mg tablets are used for the treatment of acute uncomplicated Plasmodium falciparum malaria infections, they are not used to prevent malaria or to treat severe malaria (where it has affected the brain, lungs or kidneys).

Do not take Artemether 20mg & Lumefantrine 120mg tablets

  • If you are allergic (hypersensitive) to Artemether, Lumefantrine, or any of the other ingredients (excipients) of Artemether 20mg & Lumefantrine 120mg tablets. The signs of allergic reactions include swelling of the face and mouth (angioedema), breathing problems, runny nose, skin rash or any other allergic type of reaction.
  • If you have a severe type of malaria infection where it has affected parts of your body such as the brain, lungs, or kidneys.
  • If you have a heart condition, such as changes in the rhythm or rate of the heartbeat, a slow heartbeat or severe heart disease.
  • If any member of your family (parents, grandparents, brothers or sisters) has died suddenly due to a heart problem or was born with heart problems.
  • If your doctor has told you that you have low levels of electrolytes such as potassium or magnesium in your blood.
  • If you are taking the following medicines: flecainide, metoprolol, imipramine, amitriptyline, clomipramine, certain antibiotics (macrolides, fluoroquinolones, imidazole), triazole antifungal agents, terfenadine, astemizole, cisapride.

If any of the above apply to you, tell your doctor without taking Artemether 20mg & Lumefantrine 120mg tablets.

Taking other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. In particular, do not take this medicine and tell your doctor if you are taking any of the following

  • medicines used to treat heart rhythm problems such as flecainide or metoprolol.
  • Medicines used to treat depression such as imipramine, amitriptyline or clomipramine.
  • Medicines used to treat infections called: antibiotics, including the following types; macrolides, fluoroquinolones or imidazole; triazole antifungal agents.
  • Medicines used to treat allergies or inflammation called ‘non-sedating antihistamics’ such as terfenadine or astemizole.
  • Cisapride-a medicine used to treat stomach problems.

If you are taking any of the above medicines, do not take Artemether 20mg & Lumefantrine 120mg tablets.

Taking Artemether 20mg & Lumefantrine 120mg tablets with food and drink

Artemether 20mg & Lumefantrine 120mg tablets should be taken with food or drinks rich in fat such as milk. Please ask your doctor for advice on the best food or drinks to take Artemether 20mg & Lumefantrine 120mg tablets with.

Driving and using machines

Artemether 20mg & Lumefantrine 120mg tablets may make you feel sleepy, dizzy or generally weak. If this happens to you, do not drive or use any tools or machines.

Pregnancy and breast feeding

Tell your doctor if you are pregnant, think you may be pregnant or become pregnant while taking Artemether 20mg & Lumefantrine 120mg tablets. Artemether 20mg & Lumefantrine 120mg tablets must not be used during the first 3 months of pregnancy if it is possible for the doctor to give an alternative medicine first. In the later stages of pregnancy, you should take Artemether 20mg & Lumefantrine 120mg tablets only if clearly necessary. Your doctor will discuss with you the potential risk of taking Artemether 20mg & Lumefantrine 120mg tablets during pregnancy.

You should not breast feed while you are taking Artemether 20mg & Lumefantrine 120mg tablets. Once you have finished taking Artemether 20mg & Lumefantrine 120mg tablets you should not re-start beast feeding for at least 28 days after you have taken the last tablet.

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Ask your doctor or pharmacist for advice before taking any medicine during pregnancy or while you are breast-feeding.

How to take Artemether 20mg & Lumefantrine 120mg

Always take or give the Artemether 20mg & Lumefantrine 120mg tablets exactly as your doctor or health care provider has told you. Follow your doctor’s instructions carefully and complete the full treatment with 6 doses over a three-day course of medication. All tablets should be taken for a complete cure. The full treatment is needed to kill all the parasites; if the treatment is not completed even when you feel better, malaria will come back. If you are unsure about how to take, please ask your doctor.

Taking or giving Artemether 20mg and Lumefantrine 120mg tablets

  • The tablets should be taken with food or drinks rich in fat such as milk. Please ask your doctor for advice on the best food or drinks to atke Artemether 20mg & Lumefantrine 120mg tablets with.
  • If you feel worse or are too unwell to eat or drink, please talk to your doctor.
  • If you are sick (vomit) within 1 hour of taking the tablet take another dose. If in doubt, talk to your doctor.
  • When given to small children or infants, the tablets may be crushed.

The usual dose of Artemether 20mg & Lumefantrine 120mg tablet is as follows

A six-dose regimen is recommended within 1 to 4 tablets per dose depending on body weight The 6 doses should be taken over a three days course of medication. A full three days treatment course is required to completely cure from the disease.

WeightAge (in years)Day 1 0 hrs 8 hrs afterDay 2 morning eveningDay 3 morning evening
5 to less than 15kg< 31 tablet (am) 1 tablet (pm)1 tablet (am) 1 tablet (pm)1 tablet (am) 1 tablet (pm)
15 to less than 25kg≥ 3-82 tablets (am) 2 tablets (pm)2 tablets (am) 2 tablets (pm)2 tablets (am) 2 tablets (pm)
Adults & children 25kg less than 35kg≥ 9-143 tablets (am) 3 tablets (pm)3 tablets (am) 3 tablets (pm)3 tablets (am) 3 tablets (pm)
> 35kg> 144 tablets (am) 4 tablets (pm)4 tablets (am) 4 tablets (pm)4 tablets (am) 4 tablets (pm)

If you have taken more Artemether 20mg & Lumefantrine 120mg tablets than required, contact your doctor immediately or go to your nearest casualty department. Remember to take the medicine with you, even if it is empty and show it to your doctor or the staff in the casualty department.

If you forget to take Artemether 20mg & Lumefantrine 120mg tablets, take your tablets as soon as you remember. Then go on as before, i.e. take the next dose after the recommended time interval.

If you have any further questions on the use of this product, ask your doctor, health care provider or pharmacist.

Possible side effects

Like all medicines Artemether 20mg & Lumefantrine 120mg tablets can have side effects, although not everybody gets them. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor, health care provider or pharmacist.

Rare (affecting less than 1 in 1000 patients)

If you get rash, swelling of the face, lips, tongue or throat with difficulty in swallowing or breathing, tell your doctor straight away. These are signs of an allergic reaction.

Very common (affecting more than 1 in 10 patients)

Fast heart beat, headache, dizziness, cough, being sick (vomiting), stomach pain, feeling sick (nausea), joints or muscle aching, loss of appetite, general weakness, tiredness, trouble with sleeping.

Common (affecting less than 1 in 10 patients)

Heart rhythm disturbances (called Qtc prolongation), symptoms such as unexplained persistent nausea, stomach problems, loss of appetite or unusual tiredness or weakness (signs of liver problems), diarrhoea, abnormal walking, tingling or numbness of the hands and feet, a rash or itching on the skin, insomnia.

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