Ascorbyl Palmitate

Ascorbyl Palmitate

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Ascorbyl palmitate is a practically odorless, white to yellowish powder.

Nonproprietary Names

BP: Ascorbyl PalmitatePhEur: Ascorbyl PalmitateUSP-NF: Ascorbyl Palmitate

Ascorbyl Palmitate

Synonyms

L-Ascorbic acid 6-palmitate; ascorbylis palmitas; E304; 3-oxo-Lgulofuranolactone 6-palmitate; vitamin C palmitate.

Chemical Name and CAS Registry Number: L-Ascorbic acid 6-hexadecanoate [137-66-6]

Empirical Formula and Molecular Weight: C22H38O7 414.54

Functional Category: Antioxidant.

Applications in Pharmaceutical Formulation or Technology

Ascorbyl palmitate is primarily used either alone or in combination with alpha tocopherol as a stabilizer for oils in oral pharmaceutical formulations and food products; generally 0.05% w/v is used. It may also be used in oral and topical preparations as an antioxidant for drugs unstable to oxygen.

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The combination of ascorbyl palmitate with alpha tocopherol shows marked synergism, which increases the effect of the components and allows the amount used to be reduced. The solubility of ascorbyl palmitate in alcohol permits it to be used in nonaqueous and aqueous systems and emulsions.

Method of Manufacture

Ascorbyl palmitate is prepared synthetically by the reaction of ascorbic acid with sulfuric acid followed by re-esterification with palmitic acid.

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