Asdoxin (Doxycycline Capsules BP)

Asdoxin (Doxycycline Capsules BP)

Asdoxin (Doxycycline Capsules BP)

The active ingredient of Asdoxin is Doxycycline hyclate. Each capsule contains Doxycycline hyclate BP equivalent to 100mg of anhydrous Doxycycline.

Clinical pharmacology

Doxycycline acts bacteriostatically by binding with ribosomes and thus inhibiting the bacterial protein synthesis. In high dose it is also detrimental to the protein synthesis in human cells. Like other tetracyclines, doxycycline is a broad spectrum antibiotic and it is active against a very large number of microorganisms.

Indications

Doxycycline is indicated in the treatment of respiratory tract infections, urinary tract infections, sexually transmitted diseases, dermatological infections, ophthalmic infections and rickettsial infections.

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Dosage

Adult: on the first day of treatment, 200mg/day is recommended. The treatment followed by 100mg/day. Administration of both doses may be given as a single dose or multiple doses. In case of severe infections like chronic infections of urinary tract 100mg/every 12 hours is recommended. Doxycycline capsules should be given with plenty of fluid, with the patient in upright position and well before retiring to bed. It may be given with food or milk if gastric irritation occurs.

Children: not recommended

Contraindications

Doxycycline is contraindicated in patients with rare hereditary problems of fructose intolerance, glucose-galactosemalabsorption or sucrose-isomaltase insufficiency. Use of drugs of the tetracycline class drugs during tooth development may cause permanent discoloration of the teeth (yellow-grey-brown). Enamel hypoplasia has also been reported. Doxycycline is therefore contraindicated in these groups of patients and in children under the age of 12 years.

Adverse effects

  • Gastrointestinal disturbance
  • Tooth discoloration
  • Esophageal ulceration may be particular if capsules are taken with insufficient fluid or recumbent posture.
  • Anosmia
Drug interactions

The absorption of Doxycycline is affected by antacid and iron preparation. Malabsorption of Doxycycline may be accelerated by drugs that include hepatic enzymes such as alcohol (chronic use), rifampicin and antiepileptics including carbamazepine, phenobarbital, phenytoin and primidone.

Sodium bicarbonate, colestipol, cholestyramine, kaolin, pectin, cimetidine or sucralfate are reported to reduce absorption of doxycycline. The nephrotoxic effects may be exacerbated by diuretics, methoxyflurane or other potentially nephrotoxic drugs.

There is an increased risk of ergotism when Doxycycline is co-administered with ergotamine and methylsergide.

Special precautions

Doxycycline capsules should be used with caution in patients with renal impairment and photosensitivity. Doxycycline has been associated with acute attacks of porphyria and is considered unsafe in porphyritic patients.

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Pregnancy: doxycycline is contraindicated during pregnancy.

Lactation:tetracyclines are excreted into milk and are therefore contraindicated to nursing mothers.

Overdosage

 Acute overdosage with antibiotics is rare. In the event of overdosage, discontinue medication. Gastric lavage plus appropriate supportive treatment is indicated. Dialysis does not alter serum half-life and thus would not be of benefit in treating cases of overdosage.

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