Benzethonium chloride occurs as a white crystalline material with a mild odor and very bitter taste.
Nonproprietary Names BP: Benzethonium Chloride JP: Benzethonium Chloride PhEur: Benzethonium Chloride USP: Benzethonium Chloride
Benzethonii chloridum; benzyldimethyl-[2-[2-(p-1,1,3,3-tetramethylbutylphenoxy) ethoxy]ethyl]ammonium chloride; BZT; diisobutylphenoxyethoxyethyl dimethyl benzyl ammonium chloride; Hyamine 1622.
Chemical Name and CAS Registry Number
N,N-Dimethyl-N-[2-[2-[4-(1,1,3,3-tetramethylbutyl)phenoxy] ethoxy]ethyl]benzene-methanaminium chloride [121-54-0]
Empirical Formula and Molecular Weight C27H42ClNO2 448.10
Functional Category Antimicrobial preservative; antiseptic; disinfectant.
Applications in Pharmaceutical Formulation or Technology
Benzethonium chloride is a quaternary ammonium compound used in pharmaceutical formulations as an antimicrobial preservative. Typically, it is used for this purpose in injections, ophthalmic and otic preparations at concentrations 0.01–0.02% w/v. Benzethonium chloride may also be used as a wetting and solubilizing agent, and as a topical disinfectant.
In cosmetics such as deodorants, benzethonium chloride may be used as an antimicrobial preservative in concentrations up to 0.5% w/v. The physical properties and applications of benzethonium chloride are similar to those of other cationic surfactants such as cetrimide.
Method of Manufacture
p-Diisobutylphenol is condensed in the presence of a basic catalyst with b,b0-dichlorodiethyl ether to yield 2-[2-[4-(1,1,3,3-tetramethylbutyl) phenoxy]ethoxy]ethyl chloride. Alkaline dimethylamination then produces the corresponding tertiary amine which, after purification by distillation, is dissolved in a suitable organic solvent and treated with benzyl chloride to precipitate benzethonium chloride.
Benzalkonium chloride; cetrimide