Bronopol is a white or almost white crystalline powder; odorless or with a faint characteristic odor.
- BP: Bronopol
2-Bromo-2-nitro-1,3-propanediol; b-bromo-b-nitrotrimethyleneglycol; Myacide.
Chemical Name and CAS Registry Number
Empirical Formula and Molecular Weight
Antimicrobial preservative; antiseptic.
Applications in Pharmaceutical Formulation or Technology
Bronopol 0.01–0.1% w/v is used as an antimicrobial preservative either alone or in combination with other preservatives in topical pharmaceutical formulations, cosmetics, and toiletries; the usual concentration is 0.02% w/v.
Method of Manufacture
Bronopol is synthesized by the reaction of nitromethane with paraformaldehyde in an alkaline environment, followed by bromination. After crystallization, bronopol powder may be milled to produce a powder of the required fineness.