Butylated hydroxytoluene occurs as a white or pale yellow crystalline solid or powder with a faint characteristic phenolic odor.
- BP: Butylated Hydroxytoluene
- PhEur: Butylhydroxytoluene
- USP-NF: Butylated Hydroxytoluene
Agidol; BHT; 2,6-bis(1,1-dimethylethyl)-4-methylphenol; butylhydroxytoluene; butylhydroxytoluenum; Dalpac; dibutylated hydroxytoluene; 2,6-di-tert-butyl-p-cresol; 3,5-di-tert-butyl-4- hydroxytoluene; E321; Embanox BHT; Impruvol; Ionol CP; Nipanox BHT; OHS28890; Sustane; Tenox BHT; Topanol; Vianol.
Chemical Name and CAS Registry Number
2, 6-Di-tert-butyl-4-methylphenol [128-37-0]
Empirical Formula and Molecular Weight
Functional Category: Antioxidant.
Applications in Pharmaceutical Formulation or Technology
Butylated hydroxytoluene is used as an antioxidant in cosmetics, foods, and pharmaceuticals. It is mainly used to delay or prevent the oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.
Butylated hydroxytoluene is also used at 0.5–1.0% w/w concentration in natural or synthetic rubber to provide enhanced color stability. Butylated hydroxytoluene has some antiviral activity and has been used therapeutically to treat herpes simplex labialis.
Method of Manufacture
Prepared by the reaction of p-cresol with isobutene.