Vaginal epithelium is permeable to a wide range of substances, including steroids, prostaglandins, antibiotics, estrogens, and spermicidal agents. Most steroids are readily absorbed by vaginal epithelium, leading to their higher bioavailability
The buccal and sublingual mucosae in the oral cavity provide an excellent alternative for the delivery of certain drugs. Oral transmucosal absorption is generally rapid because of the rich vascular supply to the mucosa.
Rectal administration provides rapid absorption of many drugs and is an alternative when oral administration is inconvenient because of the inability to swallow or because of GI side effects such as nausea, vomiting, and irrigation
The SC route is used for small volume injections, typically 2 mL or less. Subcutaneous means under the skin. SC injections are administered beneath the surface of the skin, between the dermis and muscle.
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