Cefazolin for Injection USP

Cefazolin for Injection USP

Share this
Advertisement

Cefazolin for Injection USP is a sterile, non-pyrogenic, single use, packaged combination of Cefazolin Sodium USP (lyophilized) and sterile iso-osmotic diluent in the sterile container. The Container is a flexible dual chamber container. After reconstitution the approximate osmolality for Cefazolin for Injection USP and Dextrose Injection USP is 290 mOsmol/kg.

The drug chamber is filled with sterile lyophilized Cefazolin Sodium USP, a semisynthetic cephalosporin and has the following IUPAC nomenclature: Sodium (6R,-7R)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate.

Antibiotic Class: First-Generation Cephalosporin

Antimicrobial Spectrum:

Gram-positive bacteria: methicillin-susceptible Staphylococcus aureus (MSSA), coagulase –negative Staphylococci, penicillin-susceptible Streptococcus pneumoniae, Streptococci spp.

Gram-negative bacteria: Moraxella catarrhalis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis

Mechanism of Action:

Cephalosporins exert bactericidal activity by interfering with the later stages of bacterial cell wall synthesis through inactivation of one or more penicillin-bindin g proteins and inhibiting cross-linking of the peptidoglycan structure. The cephalosporins are also thought to play a role in the activation of bacterical cell autolysins which may contribute to bacterial cell lysis.

Advertisement

Indications:

Treatment of respiratory tract, skin, genital, urinary tract, biliary tract, bone and joint infections, and septicemia due to susceptible gram-positive cocci (exceptEnterococcus); some gram-negative bacilli including E. coli, Proteus, and Klebsiella may be susceptible; surgical prophylaxis

Adverse Reactions:

Hematologic: Neutropenia, leukopenia, eosinophilia, thrombocytopenia, thrombocytosis, impaired platelet aggregation

Dermatologic: Rash (maculopapular), puritis, urticaria

Gastrointestinal: Diarrhea

Hepatic: Abnormal liver function tests

Renal: Interstitial nephitis

Other: Anaphylaxis

Dosage: IV/IM: 500mg/10ml injection 1gram powder for reconstitution (IM)

Adult dose: 1-2g IV/IM q8h

Mild infections: 250-500 mg IV/IM q8h

Moderate to severe infections: 0.5-1 g IV/IM q6-8h

Severe, life-threatening infections: 1-1.5 g IV/IM q6h

Perinatal GBS disease, intrapartum prophylaxis: 2 g IV x 1 dose (started at time of labor or rupture of membranes) then 1 g IV q8h until delivery

Pre-operative use: 1 g IV/IM 0.5-1 hr prior to surgery, then 0.5-1 g IV/IM q6-8h x 24 hr

Contraindications/Warnings/Precautions:

Contraindications: Hypersensitivity to cephalosporins

Precautions: hypersensitivity to penicillins

Drug Interactions: Live Typhoid Vaccine – decreased immunological response to the typhoid vaccine

Pregnancy Risk Factor: B

Brand names/Manufacturer: ACEF (SmithKline Beecham – USA, CANADA,) · AREUZOLIN (Areu – SPAIN) · BAKTOZIL (Chephasaar – GERMANY) · BASOCEF (DeltaSelect – GERMANY) · BIAZOLINA (Fermenti – ITALY) · BIOZOLIN (Novartis – GREECE) · BOR-CEFAZOL (Proter – ITALY) · BRIZOLINA (Bristol-Myers Squibb – SPAIN) · CAMIL (Martin – SPAIN) · CARICEF (Antibioticos – SPAIN) · CEFABIOZIM (IPA – ITALY) · CEFACENE (Centrum -SPAIN) · CEFACIDAL (Bristol-Myers Squibb – FRANCE, NETHERLANDS, BELGIUM, SOUTH AFRICA, MEXICO, TAHILAND) · CEFADREX (Vir – SPAIN) · CEFAKES (Inexfa – SPAIN) · CEFALIN (Atlantic – THAILAND) · CEFAMEZIN (Pharmacia . – ITALY, JAPAN, HONG KONG, ISRAEL, THAILAND) · CEFAMEZIN (Knoll – SPAIN, PORTUGAL, BRAZIL, AUSTRALIA) · CEFAMUSEL (Cruz – SPAIN) · CEFA RESAN (Alacan – SPAIN) · CEFAZIL (Italfarmaco – ITALY) · CEFAZILLIN (TP- THAILAND) · CEFAZINA (Chemil – ITALY) · CEFAZOL (General Drugs – THAILAND) · CEFAZOLIN (various generic manufacturers -USA, CANADA)) ·

Resources





Advertisement
Share this

Leave a Reply