Cefazolin for Injection USP

Cefazolin for Injection USP

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Cefazolin for Injection USP is a sterile, non-pyrogenic, single use, packaged combination of Cefazolin Sodium USP (lyophilized) and sterile iso-osmotic diluent in the sterile container. The Container is a flexible dual chamber container. After reconstitution the approximate osmolality for Cefazolin for Injection USP and Dextrose Injection USP is 290 mOsmol/kg.

The drug chamber is filled with sterile lyophilized Cefazolin Sodium USP, a semisynthetic cephalosporin and has the following IUPAC nomenclature: Sodium (6R,-7R)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate.

Antibiotic Class: First-Generation Cephalosporin

Antimicrobial Spectrum:

Gram-positive bacteria: methicillin-susceptible Staphylococcus aureus (MSSA), coagulase –negative Staphylococci, penicillin-susceptible Streptococcus pneumoniae, Streptococci spp.

Gram-negative bacteria: Moraxella catarrhalis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis

Mechanism of Action:

Cephalosporins exert bactericidal activity by interfering with the later stages of bacterial cell wall synthesis through inactivation of one or more penicillin-bindin g proteins and inhibiting cross-linking of the peptidoglycan structure. The cephalosporins are also thought to play a role in the activation of bacterical cell autolysins which may contribute to bacterial cell lysis.



Treatment of respiratory tract, skin, genital, urinary tract, biliary tract, bone and joint infections, and septicemia due to susceptible gram-positive cocci (exceptEnterococcus); some gram-negative bacilli including E. coli, Proteus, and Klebsiella may be susceptible; surgical prophylaxis

Adverse Reactions:

Hematologic: Neutropenia, leukopenia, eosinophilia, thrombocytopenia, thrombocytosis, impaired platelet aggregation

Dermatologic: Rash (maculopapular), puritis, urticaria

Gastrointestinal: Diarrhea

Hepatic: Abnormal liver function tests

Renal: Interstitial nephitis

Other: Anaphylaxis

Dosage: IV/IM: 500mg/10ml injection 1gram powder for reconstitution (IM)

Adult dose: 1-2g IV/IM q8h

Mild infections: 250-500 mg IV/IM q8h

Moderate to severe infections: 0.5-1 g IV/IM q6-8h

Severe, life-threatening infections: 1-1.5 g IV/IM q6h

Perinatal GBS disease, intrapartum prophylaxis: 2 g IV x 1 dose (started at time of labor or rupture of membranes) then 1 g IV q8h until delivery

Pre-operative use: 1 g IV/IM 0.5-1 hr prior to surgery, then 0.5-1 g IV/IM q6-8h x 24 hr


Contraindications: Hypersensitivity to cephalosporins

Precautions: hypersensitivity to penicillins

Drug Interactions: Live Typhoid Vaccine – decreased immunological response to the typhoid vaccine

Pregnancy Risk Factor: B

Brand names/Manufacturer: ACEF (SmithKline Beecham – USA, CANADA,) · AREUZOLIN (Areu – SPAIN) · BAKTOZIL (Chephasaar – GERMANY) · BASOCEF (DeltaSelect – GERMANY) · BIAZOLINA (Fermenti – ITALY) · BIOZOLIN (Novartis – GREECE) · BOR-CEFAZOL (Proter – ITALY) · BRIZOLINA (Bristol-Myers Squibb – SPAIN) · CAMIL (Martin – SPAIN) · CARICEF (Antibioticos – SPAIN) · CEFABIOZIM (IPA – ITALY) · CEFACENE (Centrum -SPAIN) · CEFACIDAL (Bristol-Myers Squibb – FRANCE, NETHERLANDS, BELGIUM, SOUTH AFRICA, MEXICO, TAHILAND) · CEFADREX (Vir – SPAIN) · CEFAKES (Inexfa – SPAIN) · CEFALIN (Atlantic – THAILAND) · CEFAMEZIN (Pharmacia . – ITALY, JAPAN, HONG KONG, ISRAEL, THAILAND) · CEFAMEZIN (Knoll – SPAIN, PORTUGAL, BRAZIL, AUSTRALIA) · CEFAMUSEL (Cruz – SPAIN) · CEFA RESAN (Alacan – SPAIN) · CEFAZIL (Italfarmaco – ITALY) · CEFAZILLIN (TP- THAILAND) · CEFAZINA (Chemil – ITALY) · CEFAZOL (General Drugs – THAILAND) · CEFAZOLIN (various generic manufacturers -USA, CANADA)) ·


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