Cetylpyridinium Chloride

Cetylpyridinium Chloride

Cetylpyridinium Chloride

Cetylypyridinium chloride is a white powder with a characteristic odor. It is slightly soapy to the touch.

Nonproprietary Names

  • BP: Cetylpyridinium Chloride
  • PhEur: Cetylpyridinium Chloride
  • USP: Cetylpyridinium Chloride

C16-alkylpyridinium chloride; Cepacol; Cepacol chloride; Cetamiun; cetylpridinii chloridum; cetyl pyridium chloride; Dobendan; hexadecylpyridinium chloride; 1-hexadecylpyridinium chloride; Medilave; Pristacin; Pyrisept.

Chemical Name and CAS Registry Number

  • 1-Hexadecylpyridinium chloride [123-03-5]
  • 1-Hexadecylpyridinium chloride monohydrate [6004-24-6]

Empirical Formula and Molecular Weight

  • C21H38ClN 339.9 (for anhydrous)
  • C21H38ClN.H2O 358.1 (for monohydrate)

Functional Category

Antimicrobial preservative; antiseptic; cationic surfactant; disinfectant; solubilizing agent; wetting agent.

Applications in Pharmaceutical Formulation or Technology

Cetylpyridinium chloride is a quaternary ammonium cationic surfactant, used in pharmaceutical and cosmetic formulations as an antimicrobial preservative. It is used therapeutically as an antiseptic agent; used alone or in combination with other drugs for oral and throat care; used in nonparenteral formulations licensed in the UK; and used in oral and inhalation preparations at concentrations of 0.02–1.5 mg. Mouthwashes containing cetylpyridinium chloride have been shown to inhibit plaque formation, although efficacy is variable owing to limited published data.

Method of Manufacture

Cetylpyridinium chloride is prepared from cetyl chloride by treatment with pyridine.

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