Clindamycin hydrochloride is the hydrated hydrochloride salt of clindamycin. Clindamycin is a semisynthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent compound lincomycin. The chemical name for clindamycin hydrochloride is Methyl 7-chloro-6,7,8-trideoxy-6-(1methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranosidemonohydrochloride.
Clindamycin inhibits bacterial protein synthesis by binding to the 50S subunit of the ribosome. It has activity against Gram-positive aerobes and anaerobes as well as the Gram-negative anaerobes. Clindamycin is bacteriostatic. Cross-resistance between clindamycin and lincomycin is complete. Antagonism in vitro has been demonstrated between clindamycin and erythromycin.
How to take Clindamycin
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. Clindamycin should always be swallowed whole and washed down with a full glass of water.
Use in adults
The usual dose of Clindamycin is between 150 and 450mg every six to eight hours, depending on the severity of your infection. If your doctor has prescribed Clindamycin 600mg Capsules, the usual dose is one capsule every 8 hours.
The usual dose in children is between 3 and 6mg per kg every six hours, depending on the severity of the infection. Your doctor will work out the number of capsules that you or your child should have, and how often they should be taken. If your child is unable to swallow capsules, talk to your doctor or pharmacist. Other forms of this medicine may be more suitable.
Possible side effects
• Severe, persistent or bloody diarrhoea (which may be associated with stomach pain or fever). This is a side effect which may occur during or after completing treatment with antibiotics and can be a sign of serious bowel inflammation.
• Signs of a severe allergic reaction such as sudden wheeziness, difficulty in breathing, swelling of eyelids, face or lips, rash or itching (especially affecting the whole body).
• Blistering and peeling of large areas of skin, fever, cough, feeling unwell and swelling of the gums, tongue or lips.
• Yellowing of the skin and whites of the eyes (jaundice).
• Effects on your nervous system: impaired sense of taste.
• Effects on your skin: reddening of the skin, skin rash, itching (hives).
• Effects on your stomach and intestines: throat ulcers, sore throat, feeling sick, being sick, stomach pain and diarrhoea.
• Effects on your blood system: reduced numbers of blood cells which may cause bruising or bleeding or weaken the immune system.
• Effects on your liver: poor liver function.
• Effects on your genital area: vaginal infection.
Erythromycin (macrolides): In-vitro antagonism – clinical significance unknown skeletal muscle relaxants (atracurium, vecuronium, pancuronium, cyclobenzaprine, and others): enhanced neuromuscular blockade.
Pregnancy Risk Factor: B