Cloxacillin | Penicillin antibiotic

Cloxacillin | Penicillin antibiotic

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Treatment of bacterial infections including endocarditis, pneumonia, bone and joint infections, skin and soft-tissue infections, and sepsis that are caused by susceptible strains of penicillinase-producing staphylococci.

Note: Exhibits good activity against Staphylococcus aureus; has activity against many streptococci, but is less active than penicillin and is generally not used in clinical practice to treat strep tococcal infections. Antibiotic Class: Penicillin (penicillinase-resistant penicillin)


Antimicrobial Spectrum: Staphylococcus spp., Streptococcal spp.

Mechanism of Action:

Exerts bactericidal activity via inhibition of bacterial cell wall synthesis by binding one or more of the penicillin binding proteins (PBPs). Exerts bacterial autolytic effect by inhibition of certain PBPs related to the activation of a bacterial autolytic process.

Adverse Effects:

Hematologic: neutropenia, inhibition of platelet aggregation CNS: seizures Hepatic: transient increases in transaminases Other: Jarisch-Herxheimer Reaction (fever, chills, sweating, tachycardia, hyperventilation, flushing, and myalgia)


Adult: 250-500mg po q6h

Pediatric: above 1 month and above 20 kg: 50-100 mg/kg/day po in 4 divided doses  

20 kg and above: usual adult dose


Contraindications: Anaphylaxis to cloxacillin or other penicillins

Precautions: Cephalosporin hypersensitivity

Drug Interactions:

Contraceptives – decreased contraceptive effectiveness Live Typhoid

Vaccine – decreased immunological response to the typhoid vaccine

Probenecid – increased cloxacillin levels Warfarin – decreased anticoagulant effectiveness

Pregnancy: Category B: No evidence of risk in humans but studies inadequate.

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