CodimeX-CT is a phenothiazine class of antihistamines which works by competitive reversible blockade of histamine receptor site on tissues hence inhibition of the action of Histamines ( a substance in the body that causes allergic symptoms). It exerts its antihistaminic affect through activity against both the Histamine-mediated early phase of the allergic reaction and the late phase which is characterized by migration of inflammatory cells to the site of the reaction. In patients with allergic conjunctivitis it acts by increasing the conjunctival reaction threshold. Cetrizine has a rapid onset and long duration of action.
Codimex-ct is used to relieve the following symptoms:
- Seasonal allergic rhinitis (Hay fever): this is due to allergens such as ragweed, grass and tree pollen in adults and children 2 years of age and older. Symptoms treated effectively include sneezing, rhinorrhea, nasal pruritis, occular pruritis, tearing and redness of the eyes.
- Perennial allergic rhinitis: this is due to allergens such as dust, mites, animal dander and molds in adults and children 6 months of age and older. Symptoms treated effectively include sneezing, rhinorrhea, postnasal discharge, nasal pruritis, occular pruritis and tearing.
- Chronic urticaria: codimex-ct is also used in the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 months of age and older. It significantly reduces the occurrence, severity and duration of hives and significantly reduces pruritis.
Cetrizine is rapidly absorbed from the gastro-intestinal tract after oral administration, peak plasma concentration being attained in about one hour. Food delays the time to peak plasma concentrations but does not decrease the amount of drug absorbed. It is highly bound to plasma proteins and has an elimination half-life of about 10 hours. Trace quantities of centrizine have been detected in breast milk. Excretion is primarily through urine mainly as unchanged drug. Centrizine does not appear to cross the blood brain barriers to a significant extent.
Dosage and administration.
Cetrizine can be taken without regard to food consumption
Adults and children over 6 years: one tablet daily; two 5ml spoonfuls daily
children 2 to 6 years: half a tablet daily; one 5ml spoonfuls daily
or as directed by a doctor
In patients who have shown hypersensitivity or idiosyncrasy to cetrizine or its parent compound – Hydroxyzine. Lactating mothers should not take Codimex-CT. Pregnant women should consult a healthcare professional before use.
No significant drug interactions have been found since centrizine appears to have low hepatic metabolism and little arrythmogenic potential
Drowsiness occurs in 14% of the patients. Fatigue, dry mouth, stomach pain, diarrhoea, nausea and vomiting, headache have been reported with cetrizine.