Diclopar is indicated for pain and inflammation in rheumatic disease, sprains, sports injury, dental pain, musculoskeletal disorders, acute gout and post-operative pain
Dosage regimen and direction for use: as directed by the physician or 1-2 tablets every six to eight hours
Serious hepatic impairment and in patients with history of hypersensitivity to NSAIDs, asthmatic patients, in angioedema, urticarial or rhinitis
Side effects ad adverse reactions
It is well tolerated by the stomach because of weak peripheral cyclo-oxygenase inhibitory effect. Adverse effects are rare but include skin rash, allergy, gastro-intestinal discomforts, nausea, diarrhea and occasionally bleeding and ulceration.
Precautions and warnings
Dicloper should be given with care to patients with impaired kidney or liver function, peptic ulceration and asthma. Keep the medicine out of reach of children
Symptoms of overdose
Symptoms of overdose include vomiting, anorexia, nausea and epigastric pain. These occur during the initial 24 hours and may persist for a week or more. Clinical manifestations of hepatic necrosis become evident within two to four days of ingestion of toxic doses. Initially plasma transaminases are elevated and the concentration of bilirubin in plasma may be increased; in addition the prothrombin time is prolonged. Acute renal failure also occurs in some patients
Treatment of overdose
Early diagnosis is vital in the treatment of Diclopar over dosage and methods are available for the rapid determination of the plasma paracetamol concentration. However therapy should not be delayed while awaiting laboratory results, if the history suggests a significant over dosage. Vigorous supportive therapy is essential when the intoxication is severe.
Gastric lavage should be performed in all cases, preferably within the first four hours of ingestion. Activated charcoal usually is not administered because it can absorb the antidote, which is N-acetyl cysteine, and reduces its efficacy. The principal antidote treatment is the administration of sulfahdryl compounds