DICLORAN® Gel (Diclofenac gel BP)
DICLORAN®, the brand of Diclofenac, is an anti-inflammatory and analgesic agent. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID). In pharmacologic studies, diclofenac has shown anti-inflammatory, analgesic and anti-pyretic activity
- Dicloran Gel is an anti-inflammatory and analgesic preparation designed for external application. It contains a quantity of active substance equivalent to 1% Diclofenac Sodium Dicloran Gel can be easily rubbed into the skin due to its unique gel base
- Dicloran Gel has major anti-inflammatory properties which apparently are related to the inhibition of cyclo-oxygenase, a decrease in prostaglandin synthesis and an increase in the re-uptake of arachidonic acid into cellular pools.
- Dicloran Gel is suitable for use in inflammatory and degenerative rheumatic diseases, as well as for the treatment of post-traumatic inflammation and swelling
Local symptomatic relief of pain and inflammation in trauma of tendons, ligaments, muscles and joints; e.g. due to sprains, strains and bruises; localized forms of soft tissue rheumatism. Topical therapy of osteoarthritis of superficial joints and acute musculoskeletal disorders e.g. tenosynovitis, myositis, bursitis.
Dosage, administration and directions for use
Depend ing on the size of the painful site to be treated, apply 2-4 gm Dicloran Gel 3-4 times daily to the affected area and rub in gently.
Dicloran Gel is contraindicated in patients with a history of hypersensitivity to Diclofenac, Aspirin and other non-steroidal anti-inflammatory drugs.
As with other NSAIDs, anaphylactoid reactions may occur in patients without prior exposure to diclofenac. Diclofenac Sodium should be given with caution to patients with the aspirin triad. The triad typically occurs in asthmatic patients who experience rhinitis with or without nasal polyps, or who exhibit severe potentially fatal bronchospasm after taking aspirin or other NSAIDs.
Symptoms and treatment of overdosage
Due to the low systemic absorption of topically applied Dicloran Gel, overdosage is unlikely. There have been no reports of ingestion of Dicloran Gel. In the event of oral ingestion, stomach should be emptied by lavage, symptomatic treatment and supportive care should be given.
Although the systemic absorption of Dicloran Gel is low, concomitant oral administration of other NSAIDs, such as aspirin an anti-inflammatory/ analgesic doses should be minimized.
- Dicloran Gel should be applied only to intact skin surface and not to skin wounds or open injuries. It should not be allowed to come into contact with the eyes or with mucous membranes.
- Where Diclofenac Gel is applied to relatively large areas of skin and over a prolonged period, the possibility of systemic side effects cannot be completely excluded.
- Since no experience has been acquired with Dicloran Gel in pregnant women, it is not recommended for use during pregnancy.
Dicloran Gel is usually well tolerated. Itching, reddening or smarting of the skin or outbreak of a skin rash may occasionally occur.