DIODOL® (Paracetamol tablets 500mg BP)

DIODOL® (Paracetamol tablets 500mg BP)

DIODOL® (Paracetamol tablets 500mg BP)

DIODOL tablets are recommended for treatment of headache (including migraine), toothache, neuralgia, backache, pain caused by rheumatism, dysmenorrheal. Diodol is also effective at lowering the high temperature. Since Diodol has analgesic and antipyretic activities and weak anti-inflammatory activity, it is often the analgesic and antipyretic choice especially in patients when salicylates or other NSAIDs are contraindicated.

Dosage regimen and directions for use

The usual doses are 0.5g ( 1 tablet) every four to six hours up to maximum of 4g daily.

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The usual children dose is

Under 3 months; 10 mg/kg body weight. (If jaundiced)

  • 3 months to 1 year; 60 mg to 120 mg
  • 1 year to 5 years; 120 mg to 250mg
  • 6 years to 12 years; 250mg to 500mg

These doses may be given every 4 to 6 hours for post immunization pyrexia, a dose of 60mg has been recommended for children ages 2 to 3 months. A second dose may be given after 4 to 6 hours. If pyrexia persists after that dose, the parent should seek medical advice.

Contraindications

Diodol should not be taken by patients who are allergic to paracetamol or any ingredient in the dosage form or by patients with severe kidney or liver impairments.

Side effects and adverse effects

Side effects of paracetamol are rare and usually mild although hematological reactions including thrombocytopenia, leucopenia, pancytopenia, netropenia and agranulocytosis have been reported. Skin rashes and other hypersensitivity reactions occur occasionally.

Drug interactions

The list of paracetamol toxicity may be increased in patients receiving other potentially hepototoxic drugs that induce liver microsomal enzymes.

The absorption of paracetamol may be accelerated by drugs such as metoclopramide. Excretion may be affected and plasma concentrations altered when administered with probenecid.

Cholestyramine reduces the absorption of paracetamol if given within one hour of paracetamol administration.

Avoid taking paracetamol with anticoagulants e.g. warfarin.

Precautions and warnings

Due to the narrow margin between therapeutic dose and toxic dose care should be taken to avoid unnecessarily high doses of paracetamol.

Paracetamol should be given with care to patients with impaired kidney or liver function. It should also be given with care to patients with alcohol dependence.

Studies in pregnancy have shown no ill effects due to paracetamol used in the recommended dose, but doctor’s advice should be followed.

The amount of paracetamol distributed into breast milk is considered by authorities to be too small to be harmful to breast-fed infant.

Symptoms and treatment of overdosage
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Early features of overdosage (symptoms) include nausea and vomiting usually settles within 24 hours. Others include lethargy and sweating. Abdominal pain may be first indication of liver damage which is not usually apparent for 24 hours to 48 hours and sometimes may be delayed for up to 4 to 6 days after ingestion. Liver damage is generally at a maximum 76 to 96 hours after ingestion.

Hepatic failure, encephalopathy, coma and death may result.

Prompt treatment is essential, even when there are no obvious symptoms, all patients should be admitted to hospital.

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