DYCLO (Diclofenac Sodium)

DYCLO (Diclofenac Sodium)

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DYCLO (Diclofenac Sodium)

Dyclo is chemically Diclofenac Sodium, it is a potent nonsteroidal anti-inflammatory drug (NSAID) with analgesic & antipyretic properties.

Composition

Dyclo 25mg tablet: Each tablet contains 25 mg Diclofenac Sodium B.P

Dyclo 50mg tablet: Each tablet contains 50 mg Diclofenac Sodium B.P

Dyclo SR 100 tablet: Each tablet contains 100 mg Diclofenac Sodium B.P

Dyclo injection: Each 3ml ampoule contains 75 mg Diclofenac Sodium B.P

Pharmacology

Diclofenac is a very potent inhibitor of prostaglandin synthesis there by relieving pain & inflammation. The drug penetrates rapidly into synovial fluid & peak levels in synovial fluid are achieved 2 hours after peak plasma concentrations.

DYCLO 25 mg, 50 mg, & DYCLO SR 100 Tablets

Dyclo 25mg & 50mg tablets are enteric coated and are acid resistant while the Dyclo SR 100 tablet is enteric coated sustained released tablets.

The enteric coated tablets by pass the acidity of stomach and absorption occurs in the intestine. The peak plasma concentrations are achieved 2 hours after absorption. Due to being enteric coated, the gastrointestinal tolerance of Dyclo is excellent.

DYCLO INJECTION

The onset of action Dyclo (Diclofenac) injection is within 16 minutes and the duration of effect is up to 15 hours. The injection should be administered deep into the gluteal muscle in severe arthritic conditions, trauma, orthopaedic manipulations and postoperatively to control pain & inflammation.

Indications

Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Cervical spondylitis, Gout, Capsulitis of shoulder, Frozen shoulder, Lower back pain, Disc lesions, Dental pain, Musculoskeletal pain/strain, Traumatic pain, Synovitis, Tenosynovitis, Bursitis, Dysmenorrhoea, Renal colic and Postoperative pain.

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Contraindications

Sensitivity to Diclofenac Sodium, Peptic ulceration, Asthma and to patients hypersensitive to aspirin & other prostaglandin synthesis inhibitors.

Side effects

Rarely mild gastrointestinal upset has been reported. Other rarely observed side effects include headache, fluid retention & peripheral oedema.

Precautions

Severe hepatic, cardiac or renal insufficiency & history of peptic ulcer, use in pregnancy should be avoided due to risk of premature closure of ductus arteriosus with prostaglandin inhibitors.

Dosage

Dyclo 25mg tab: Usual dose is two tablets 2 or 3 times daily or as directed by the physician.

Dyclo 50mg tab: Usual dose is one tablet 2 or 3 times daily or as directed by the physician

Dyclo SR 100 tab: Usual dose is one tablet daily or as directed by the physician.

Dyclo injection 75mg/3ml ampoule

One ampoule twice a day (after every 12 hours) in acute arthritic conditions, trauma, orthopaedic conditions and to control severe pain after surgery or as directed by the physician. The injection should be administered deep into the gluteal muscle.

Dosage for children

1 to 3mg per kg daily in divided doses or as advised by the physician. Not recommended for children under 8 years of age.

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