Heparin Injection Bp: An anticoagulant drug

Heparin Injection Bp: An anticoagulant drug

Heparin Injection BP

Is a heterogeneous group of straight-chain mucopolysaccharides, called gycosaminoglycan, having anticoagulant properties. heparin injection BP, is sterile solution of Heparin Sodium derived from porcine intestinal mucosa, standardized for anticoagulant activity. it is to be administered by intravenous or deep subcutaneous routes. The potency is determined by a biological assay using USP reference standard based on Heparin activity per milligram.

Actions and Clinical Pharmacology (Mechanism of action of Heparin)

Heparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both vitro and in vivo. Heparin acts at multiple sites in the normal coagulation system. Small amounts of Heparin in combination with antithrombin iii ( Heparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin .


Once active thrombosis have developed, larger amounts of Heparin can inhibit further coagulation to fibrin. Bleeding time is usually unaffected by Heparin. Clotting time is prolonged by full therapeutic doses of heparin; in most cases, it is not measurably affected by low doses of Heparin.

Indications and clinical uses of heparin

Heparin Sodium injection is indicated for: Anticoagulant therapy in prophylaxis and treatment of venous thrombosis and is extension; low dose regimen for prevention of postoperative deep venous thrombosis and pulmonary embolism in patients undergoing major abdominothoracic surgery or who , for other reasons are at risk of developing thromboembolic disease.


  • Severe thrombocytopenia
  • when suitable blood coagulation tests, e.g, the whole blood clotting time, partial thromboplastin time, etc, can not be performed at appropriate intervals ( this contraindication refers to full dose heparin; there is no need to monitor  coagulation parameters in patients receiving low dose heparin)
  • An uncontrolled active bleeding state, except when this is due to disseminated intravascular coagulation.


Hemorrhage can occur at virtually any site in patients receiving heparin. An unexplained fall in hematocrit, fall in blood pressure or any other unexplained symptom should lead to serious consideration of a hemorrhagic event. Heparin Sodium should be used with extreme caution in disease states in which there is increased danger of hemorrhage.

Benzyl Alcohol Toxicity

Use preservative free Heparin Sodium in neonates and infants. The preservative benzyl alcohol has been associated with serious adverse events and death in pediatric patients

. the minimum amount of benzyl alcohol at which toxicity may occur is not known.



Leave a Reply

%d bloggers like this: