ISORYN

ISORYN (Ephedrine adult & paediatric nasal drops)

Share this

ISORYN

Isoryn Adult Nasal Drop is a clear, colourless liquid containing Ephedrine Hydrochloride BP 1% and isotonic vehicle to 100%.

Isoryn Paediatric Nasal Drop is a clear, colourless liquid containing Ephedrine Hydrochloride BP 0.5% and isotonic vehicle to 100%.

Pharmacological actions

Ephedrine is both an α1-adrenegic agonist. In addition, it enhances release of norepinephrine from sympathetic neurons. It is likely to decrease resistance of airflow by decreasing the volume of the nasal mucosa, this may occur by activation of α1-adrenegic receptors in venous capacitance vessels in nasal tissues that have erectile characteristics. The receptors that mediate this effect appear to be α1-adrenegic receptors. Interestingly, α2-receptors may mediate contraction of arterioles that supply nutrition to the nasal mucosa. Intense constriction of these vessels may cause structural damage to the mucosa.

Indications

It is indicated in allergic or vasomotor rhinitis and in acute rhinitis in patients with upper respiratory infections

Dosage and administration

Instill 1 to 2 drops into each nostril, 3-4 times daily for up to 7 days.

Contraindications

Contraindicated in patients who are taking monoamine oxidase inhibitors

Precautions

Should be used with caution in patients with hypertension and in men with prostatic enlargements.

Side effects:

Excessive or chronic use may lead to rebound hyperemia and worsening of symptoms. Local irritation may occur.

Share this

Leave a Reply