Metoclopramide Hydrochloride | prokinetic agent

Metoclopramide Hydrochloride

Metoclopramide Hydrochloride

Metoclopramide is a medication used mostly for stomach and esophageal problems as it is a prokinetic agent. It is commonly used to treat and prevent nausea and vomiting to help with emptying of the stomach in people with delayed stomach emptying, gastroenteritis and to help with gastroesophageal reflux disease. Metoclopramide is an antiemetic. It works on part of your brain that prevents you from feeling sick (nausea) or being sick (vomiting)


This medication is used to treat certain conditions of the stomach and intestines. Metoclopramide is used as a short term treatment (4 to 12 weeks) for persistent heartburn when the usual medicines do not work well enough. It is used often for heartburn that occurs after a meal or during the day time. Treating persistent heartburn can decrease the damage done by the stomach acid to the swallowing tube (esophagus) and help healing

Metoclopramide is also used in diabetic patients who have poor emptying of their stomachs (gastroparesis). Treating gastroparesis can decrease symptoms of nausea, vomiting and stomach / abdominal fullness. Works by blocking a natural substance (dopamine). It speeds up stomach emptying and movement of the upper intestine.

This drug is not recommended for children due to an increased risk of serious side effects (such as muscle spasms/ uncontrolled muscle movement)

Do not take metoclopramide if you:

  • Are allergic to metoclopramide or any of the ingredients of this medicines
  • Have bleeding , obstruction or tear in your stomach or gut
  • You have any or may have a rare tumor of the adrenal gland, which sits near the kidney
  • Have ever had involuntary muscle spasms
  • Have epilepsy 
  • Have parkinson’s disease
  • Are taking levodopa

Do not give metoclopramide to child below 1 year.

Warning and precautions:

  • Have a history of abnormal heart beats
  • Have problem with levels of salts in your blood
  • Are using other medicines known to affect the way your heart beats
  • Have any neurological (brain) problems
  • Have liver or kidney problems.

The use of alcohol: Alcohol should not be consumed during treatment with metoclopramide because it increases the sedative effect of metoclopramide.

Driving and using machines: You may feel drowsy, dizzy or have uncontrollable twitching, jerking or writhing movements and unusual muscle tone causing distortion of the body after taking metoclopramide. This may affect your vision and also interfere with your ability to drive and use machines.

Side effects:

Drowsiness, dizziness, tiredness, trouble sleeping, agitation, headache and diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Tell your doctor if you have any serious side effects, including: mood changes, decreased sexual ability, muscle spasm, Parkinson like symptoms, abnormal breast milk production, enlarged breast, swelling of the hands, changes in the menstruation in women. This medication may rarely cause a very serious condition called neuroleptic malignant syndrome

Some products that may interact with this drug include:

  • Antipsychotic drugs : aripiprazole, haloperidol
  • Atovaquone
  • Dopamide agonist: cabergolline, pergolide, ropinirole
  • Phenothiazide: promethazine, prochloperazine, rivastigmine


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