oral fungi

Micora oral gel

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Miconazole oromucosal Gel BP 2% w/w

Miconazole possesses in vitro antifungal activity against the common dermatophytes and yeasts as well as an antibacterial activity against certain gram-positive bacilli and cocci. Its activity is based on the inhibition of the ergosterol biosynthesis in fungi and the change in the composition of the lipid components in the membrane, resulting in fungal cell necrosis.

Pharmacokinetics

When administered orally, miconazole is incompletely absorbed from the gastrointestinal tract, peak plasma levels of about 1µg per ml have been achieved after a dose of 1 g per day. Miconazole is inactivated in the body and 10-20% of an oral dose is excreted in the urine, mainly as metabolites, within 6 days. About 50% of an oral dose may be excreted unchanged in the faeces.

oral fungi
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Indications

For the treatment of fungal infections of the mouth and for fungal stomatitis occurring in association with dentures

Contraindications

Contraindicated to patients who have hypersensitivity to miconazole or to any of its ingredients and patients with liver dysfunction

Adverse effects

Gastro-intestinal discomfort such as nausea, vomiting and with long-term treatment, diarrhea.

Allergic reactions have been reported less frequently

Precautions

If giving Micora oral gel to a child, make sure that the gel does not close off the child’s throat as the child could choke on it. You should therefore place the gel in the front of the mouth-never put it at the back of the throat. If you are pregnant or are planning to become pregnant, you should talk to your doctor who will decide if you can use Micora oral gel. If you are breast feeding ask your doctor for advice.

Dosage and administration

Miconazole oral gel should be spread evenly over the affected areas of the oropharyngeal mucosa and tongue taking care to properly cover oral ulcerations and other lesions. The application of Miconazole oral gel must be repeated two to three times daily depending upon the severity of the infection. Apply the gel regularly until all signs of the infection have disappeared. Continue using for another two days after the infection has cleared. Application of the gel is preferably done after meals. For best results in treatment of oral lesions, Miconazole oral gel must be kept in contact with the affected areas as long as possible. This can be achieved by retaining the gel in the mouth for the maximum time possible. In fungal stomatitis, associated with dentures, apply the gel to the lesions in the evening and leave on overnight.

Drug interactions

You should not take Micora oral gel if you are taking any of the following medicines: A hay fever or antihistamine, Cisapride certain drugs that lower your cholesterol, Midazolam (by mouth) and triazolam, primozide, certain medicines used to treat irregular heart beat rhythms, namely quinidine and dofetilide

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