MUSCLE PLUS® oral tablets

MUSCLE PLUS® oral tablets

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(Paracetamol BP 500mg, chlorzoxazone USP 250mg and Diclofenac sodium BP 50mg)
Paracetamol is well- established analgesic and mild antipyretic, while diclofenac exhibits pronounced antirheumatic, antinflammatory, analgesic and antipyretic properties. Chlorzoxazone is a centrally-acting agent for musculoskeletal conditions

MUSCLE PLUS® is a centrally acting skeletal muscle relaxant, with sedative properties. It is used to inhibit muscle spasm


MUSCLE PLUS® is a centrally acting skeletal muscle relaxant, with sedative properties. It is used to inhibit muscle spasm. It is also a strong analgesic. It provides quick symptomatic relief from aches and pains like headache, toothaches, body ache, myalgia, sinusitis, headache, fever, flu-syndrome, primary dysmenorrhea, pain of various etiology, articular pain, rheumatoid arthritis, lumbago and painful inflammatory conditions.


MUSCLE PLUS® should not be used in presence of moderate to severe liver or kidney dysfunction, asthmatic patients, in angioedema, urticaria or rhinitis, peptic or duodenal ulcers or hypersensitivity to paracetamol, chlorzoxazone or diclofenac sodium

Dosage regimen
Adults: 1-2 tablets 3-4 times a day

Pregnancy and breast-feeding
Human and animal studies have not identified any risk of paracetamol in pregnancy or embryo-foetal ddevelopment. Diclofenac may affect closure of ductus arteriosus so its use during pregnancy should be avoided. Chlorzoxazone may increase sedative effect to the fetus. Paracetamol is excreted in breast milk but it is not known if diclofenac is excreted in human milk. Chlorzoxazone may increase sedative effect to the lactating child


Side effects and adverse reactions

MUSCLE PLUS® is very well tolerated when used as recommended. Side effects are rare and mild, although, hematological reactions like thrombocytopenia, leucopenia, pancytopenia, neutropenia and agranulocytosis have been reported. Other side effects are; skin rashes allergy, nausea, depression, diarrhoea, gastrointestinal disorders, rarely bleeding and ulceration. Chlorzoxazone may cause drowsiness

Patients taking MUSCLE PLUS should not drive or operate machinery. CNS- depressants effect of Chlorzoxazone may be enhanced by alcohol or other CNS-depressants. Urine of patients on MUSCLE PLUS may be colored orange or reddish-purple by a phenolic metabolite.
Drug is Manufactured by Zenufa

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