Muscle relaxant drugs
These are the medicines that affect skeletal muscle function and decrease the muscle tone. It maybe used to alleviate symptoms such as spasm, pain and hyperreflexia. They usually administered together with anesthetics during procedure or surgery.
They primary act as central nervous system depressants. Used in addition to rest, physical therapy, and other measures to relieve discomfort, muscle relaxants are beneficial for short term use for acute, painful muscle-skeletal conditions.
Muscle relaxants maybe classified into two groups; spasmolytics and neuromuscuar blockers.
Neuromuscular blockers are drugs that completely paralyze skeletal muscles by interfering with acetylcholine at neuromuscular junction.
GABA-B Receptor agonist. It is indicated to alleviation of severe spasticity resulting from; mutiple sclerosis and patient with spinal cord injury. It is contraindicated to hypotension patients and dyspnea when used with epidural morphine. It can be taken orally , when injected intrathecally effective CSF concentration can be achieved with result plasma concentrations 100 times less than with oral administration. side effects include dizziness, sedation and dry mouth.
Interferes with the release of calcium from the sarcoplasmic reticulum through the SR calcium channel complex to produce skeletal muscle relaxation. It is indicated to the immediately treatment of fulminant hypermetabolism of skeletal muscle characteristics of malignant hyperthermia. the drug may potentiate vecuronium-induced NMJ block. side effects include loss of grip strength and leg weakness, subjective CNS complaints from normal patients.
Acts on parts of the limbic system, the thalamus and hypothalamus to induce calming effect.
contraindication: glaucoma, drug hypersensitivity,
side effects include fatigue, drowsiness, ataxia, confusion.