Oxybutynin chloride | urinary frequency and urgency medicine

Oxybutynin chloride | urinary frequency and urgency medicine

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Oxybutynin Tablets contains a medicine called Oxybutynin hydrochloride. This belongs to two groups of medicines called “anticholinergics and “antispasmodics”. It works by relaxing the muscles of the bladder and stops sudden muscle contractions (spasms). This helps control the release of water (urine).


Mechanism of action

Oxybutynin chloride exerts a direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. Oxybutynin chloride exhibits only one fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. No blocking effects occur at skeletal neuromuscular junctions or autonomic ganglia (antinicotinic effects).



Oxybutynin chloride relaxes bladder smooth muscle. In patients with conditions characterized by involuntary bladder contractions, cystometric studies have demonstrated that oxybutynin chloride increases bladder (vesical) capacity, diminishes the frequency of uninhibited contractions of the detrusor muscle, and delays the initial desire to void. Oxybutynin chloride thus decreases urgency and the frequency of both incontinent episodes and voluntary urination.


Antimuscarinic activity resides predominately in the R-isomer. A metabolite, desethyloxybutynin, has pharmacological activity similar to that of oxybutynin in invitro studies.

Therapeutic indications

Oxybutynin chloride is indicated in adults and children over 5 years of age for the management of urgency and incontinence that characterise neurogenic bladder disorders and idiopathic detrusor instability.

Dose

Adults

The usual dosage is 5mg taken 2 to 3 times daily. The maximum recommended dose is 5mg taken 4 times daily.

Elderly patients

Initially treatment should be 2.5mg taken 2 times daily, and increased as necessary.

Children over 5 years

The usual dosage is 5mg taken twice daily. The maximum recommended dose is 5mg taken 3 times daily.

Contraindications

Oxybutynin chloride is contraindicated in patients with urinary retention, gastric retention and other severe decreased gastrointestinal motility conditions, uncontrolled narrow-angle glaucoma and in patients who are at risk for these conditions. Oxybutynin chloride is also contraindicated in patients who have demonstrated hypersensitivity to the drug substance or other components of the product.

Oxybutynin Tablets with alcohol

Oxybutynin may cause drowsiness or blurred vision. Drowsiness may be increased by consumption of alcohol.

Pregnancy

Category B1.

Oxybutynin chloride should not be prescribed to pregnant patients or patients planning pregnancy unless in the opinion of the medical practitioner, the probable benefits outweigh the potential risks to the foetus.

Breast-feeding

Oxybutynin chloride may be excreted in breast milk, and may also restrict the mammary secretion of breast milk. In consideration of potential risks to the infant, oxybutynin chloride should not be administered to women who are breastfeeding. Driving and using machines

Effects on ability to drive machines

You may feel drowsy or have blurred vision while you are taking this medicine. If this happens, do not drive or use any tools or machines.

Oxybutynin Tablets contains lactose

Oxybutynin Tablets contains lactose. If you have intolerance to some sugars, consult your doctor before taking this medicine.





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