PHYTOVITA-H (Phytomenadione Injection BP 10mg/ml)

PHYTOVITA-H (Phytomenadione Injection BP 10mg/ml)

PHYTOVITA-H (Phytomenadione Injection BP 10mg/ml)

Vitamin K1 (phytomenadione), is a procoagulant factor. As a component of a hepatic carboxylase system, Vitamin K1  is involved in the post-translational carboxylation of clotting factors II (prothrombin), VII, IX and X and the clotting inhibitors protein C and protein S.

Coumarins inhibit the reduction of vitamin K1 (quinine form) to vitamin K1 hydroquinone and also prevent the vitamin K1 epoxide arising after carboxylation from being reduced to the quinine form. Vitamin K1 is an antagonist of coumarin-type anticoagulants, e.g. phenprocoumon. It does not, however, neutralize the activity of heparin; protamine is the antagonist of heparin. Vitamin K1 is ineffective in hereditary hypoprothrombinemia or hypoprothrombinemia induced by severe hepatic failure. Lack of vitamin K1 leads to an increased tendency to hemorrhagic disease in the newborn. Vitamin K1 administration, which promotes synthesis of the above mentioned coagulation factors by the liver, can reverse an abnormal coagulation status and bleeding due to Vitamin K1 deficiency.

Dosage and administration

For problems with blood clotting or increased bleeding:

Adults and teenagers: the usual dose is 2.5 to 25mg, rarely up to 50mg, injected under the skin. The dose may be repeated if needed.

For prevention of bleeding in newborns:

The usual dose is 0.5 to 1mg, injected into a muscle or under the skin, right after delivery. The dose may be repeated after six to eight hours if needed.

Side effects of this medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur

  • Decrease appetite
  • Decreased movement or activity
  • Difficulty in breathing
  • Enlarged liver
  • General body swelling
  • Irritability
  • Muscle stiffness
  • Paleness
  • Yellow eyes or skin.

Rare with injection only

  • Difficulty in swallowing
  • Fast or irregular breathing
  • Lightheadedness or fainting
  • Shortness of breath
  • Skin rash
  • Hives and/or itching
  • Swelling of the eyelids, face or lips
  • Tightness in the chest
  • Troubled breathing and/or wheezing

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However check with your doctor if any of the side effects continue or are bothersome.

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