PULMOZYME® use with Jet Nebulizers and Compressors

PULMOZYME® use with Jet Nebulizers and Compressors

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PULMOZYME® use with Jet Nebulizers and Compressors

Read this Instructions for Use before you start taking Pulmozyme and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment.

A nebulizer and a compressor are used together to give a dose of Pulmozyme. A nebulizer changes the Pulmozyme liquid medicine into a fine mist you inhale by breathing through a mouthpiece. A compressor gives the nebulizer power and makes the nebulizer work.

Do not use any other inhaled medicines in the nebulizer at the same time. Keep all other inhaled medication systems completely separate from Pulmozyme.

Do not use a mask. Use the mouthpiece provided with each nebulizer kit.

If your child cannot breathe in or breathe out by mouth, you may use the PARI BABY™ reusable nebulizer, but you should discuss it with your doctor first. The PARI BABY™ nebulizer is the same as the PARI LC Plus Jet system, except the mouthpiece is replaced by a tight fitting face mask connected to an elbow piece.

Approved nebulizers and compressors

NebulizerCompressors
Hudson T Up-draft II® withPulmo-Aide®
Marquest Acorn II® withPulmo-Aide®
PARI LC® Plus withPARI PRONEB®
PARI BABYTM withPARI PRONEB®
Durable Sidestream® withMOBILAIRETM
Durable Sidestream® withPorta-Neb®

Supplies you will need to give a dose of Pulmozyme

  • 1 ampule of Pulmozyme
  • Compressor
  • Nebulizer cup and screw-on or snap-on cap
  • Plastic T connector (not needed for Sidestream nebulizer or PARI BABY)
  • Flexible aerosol tube (not needed for Sidestream nebulizer or PARI BABY)
  • Clean mouthpiece or PARI BABY facemask
  • Long connecting tube
  • Nose clip (optional, not needed for PARI BABY)

Preparing the jet nebulizer and compressor

Step 1. Clean a flat table surface and wash your hands.

  • Clean a flat table surface.
  • Wash your hands well with soap and water before using the Pulmozyme ampule and nebulizer. This helps prevent infection

Step 2. Gather the nebulizer and test the compressor.

  • Place the nebulizer parts on a clean, flat table surface within reach.
  • Test the compressor by turning it on and putting your finger in front of the “air out” or “air” port to feel air flowing. Turn off the compressor
  • For the MOBILAIRETM compressor only, turn the pressure control knob fully to the right for the highest pressure output.

Step 3. Gather the Pulmozyme ampule and check the expiration date.

  • Remove 1 foil pouch of Pulmozyme from the refrigerator. Open the foil pouch and remove 1 ampule of Pulmozyme. Put the remaining ampules back in the foil pouch and return them to the refrigerator.
  • Check the expiration date printed on the ampule. Do not use the Pulmozyme ampule if the expiration date has passed.

Step 4. Check the Pulmozyme ampule.

  • Check the ampule for leaks by turning it upside down and gently squeezing. Do not use the ampule if it is leaking. Throw it away and get a new one.
  • Check the Pulmozyme liquid in the ampule and make sure it is clear and free of particles. Do not use Pulmozyme if the liquid is cloudy or discolored. Take the Pulmozyme back to the pharmacy, hospital, or clinic that gave you the medicine.

Step 5. Attach the tube to the compressor.

  • Attach the long connecting tube to the “air out” or “air” port on the compressor

Step 6. Attach the mouthpiece.

  • Skip to Step 7 if you use the Sidestream nebulizer or the PARI BABY nebulizer.
  • Push the mouthpiece into the wider end of the plastic T. Attach the flex tube to the other end of the T

Step 7. Remove the cap from the cup.

  • Unscrew or unsnap the cap from the nebulize cup
  • Put the nebulizer cup on the table face up and place the cap upside down on a clean surface

Step 8. Open the Pulmozyme ampule.

  • Hold the tab at the bottom of the Pulmozyme ampule firmly. Twist off the top. Do not squeeze the body of the ampule

Step 9. Pour the full Pulmozyme dose into the nebulizer.

  • Turn the ampule upside down and squeeze gently to empty the medicine into the nebulizer cup. Keep squeezing until the ampule is empty. It is very important you squeeze all of the medicine out of the ampule
  • Screw or snap the cap onto the nebulizer cup

Step 10. Connect the plastic T.

  • Connect the plastic T to the nebulizer cap
  • If you are using the Sidetream nebulizer, attach the mouthpiece to the top of the nebulizer
  • If you are using the PARI BABY nebulizer, connect the elbow piece and mask to the nebulizer outlet

Step 11. Attach the tube to the cup.

  • Connect the open end of the long tube to the port on the bottom of the nebulizer cup by pushing up firmly
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Step 12. Turn on the compressor.

  • Turn on the compressor and check to see that mist is coming out of the nebulizer
  • If you are using the MOBILAIRETM compressor, turn the compressor control knob fully to the right, then turn on the compressor. The pressure gauge should move between 35 psi and 45 psi, the highest pressure output

Taking your dose of Pulmozyme with a nebulizer

Step 13. Breathe through the mouthpiece.

  • Skip to Step 14 if you are using the PARI BABY to give Pulmozyme to your child.
  • Place the mouthpiece between your teeth and on top of your tongue.
  • Breathe slowly in and out through your mouth. Do not block the airflow with your tongue.
  • Do not breathe through your nose. If you have problems breathing only through your mouth, use a nose clip
  • Do not be concerned if liquid droplets form in the long connecting tube during treatment. When the nebulizer begins spitting, gently tap the nebulizer cup and continue breathing until the nebulizer cup is empty or stops making mist
  • If you need to stop treatment before you are finished, or you begin coughing, turn off the compressor and do not spill any of the medicine.
  • To start treatment again, turn on the compressor and continue breathing slowly in and out through your mouth.
  • The complete treatment usually takes from 10 to 15 minutes for most nebulizers and compressors.
  • If you are using the Sidestream nebulizer with the MOBILAIRETM or Porta-Neb compressors, treatment usually takes from 2 to 6 minutes.
  • It is important to inhale the full dose of Pulmozyme. If you find a leak or feel any moisture coming from the nebulizer during treatment, turn off the compressor and check to make sure the nebulizer cap is sealed correctly before continuing

If you are using the PARI BABY nebulizer to give Pulmozyme to your child, follow the instructions below in Step 14. If not, go to Step 15

Step 14. Breathing through the facemask

  • During the treatment your child may sit, lie down or stand.
  • Place the facemask gently but firmly over your child’s nose and mouth
  • Make sure there are no air gaps between the mask and your child’s face.
  • This will help make sure that your child will get the full dose of Pulmozyme.
  • It is important that you try to keep the body of the nebulizer upright during the entire treatment. The elbow piece will allow you to move the mask for a good fit while keeping the nebulizer body upright.
  • When the nebulizer begins “spitting,” gently tap the nebulizer cup and continue treatment until the nebulizer is empty or stops making a mist
  • If you need to stop the treatment or your child begins to cough during treatment, turn the compressor off. Do not spill any Pulmozyme.
  • If you have not removed the mask and you want to begin the treatment again, turn on the compressor.
  • If you have removed the mask, repeat the steps above to replace the mask on your child’s face and restart the compressor.
  • The complete treatment usually takes from 10 to 15 minutes.

It is important that your child inhale the full dose of Pulmozyme. If you find a leak or feel moisture coming from the nebulizer during the treatment, turn off the compressor and make sure the nebulizer cap is sealed correctly before starting the compressor again

After your treatment with Pulmozyme

Step 15. Prepare the nebulizer for cleaning and storage.

  • Turn off the compressor and take apart the nebulizer system. Set aside the flex tube and the long connecting tube.

Note: The Sidestream nebulizer does not use a flex tube.

  • Throw away the Pulmozyme ampule in your household trash.
  • Follow the manufacturer’s recommendations for care of your nebulizer and compressor.

How should I store Pulmozyme?

  • Store Pulmozyme in its foil pouch in the refrigerator between 36°F to 46°F (2°C to 8°C) until you are ready to use it.
  • When traveling, Pulmozyme should be kept cold in its foil pouch.
  • Do not freeze Pulmozyme.
  • Protect Pulmozyme from excessive heat and strong light.
  • Do not use Pulmozyme if it has been left at room temperature for a total time of 24 hours or if it becomes cloudy or discolored.
  • Do not use Pulmozyme past the expiration date printed on the ampule.
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