Fluconazole, bis-triazole anti-fungal, has increase in anti-fungal activity & expanded anti-fungal spectrum. Nitrogen of azole ring binds to haem of fungal CYP450 enzyme lanosterol leads abnormalities in membrane permeability
Dermidex is indicated for the treatment of fungal infections of the skin and super infections due to Gram-positive bacteria. These include athlete’s foot, ringworm (tinea infections), intertrigo, candida nappy rash, paronychia, erythrasma, fungal infections of the outer ear and pityriasis versicolor. It may be used for nail infections.