Ocucycline® ophthalmic ointment

Tetracycline Hydrochloride Ophthalmic ointment USP 1%

Ocucycline® ophthalmic ointment, a broad-spectrum antibiotic, is a yellow coloured homogenous combination of Tetracycline hydrochloride and sterile paraffin base. It is indicated for the treatment of ocular infections when caused by susceptible microorganisms

Ocucycline® ophthalmic ointment, a broad-spectrum antibiotic, is a yellow coloured homogenous combination of Tetracycline hydrochloride


Tetracycline hydrochloride is derived from oxytetracycline that in turn is obtained from Streptomyces rimosus. Like other members of the Tetracycline family the bacteriostatic action of Ocucycline ophthalmic ointment is mediated through an interference with the protein synthesis

Ocucycline® ophthalmic ointment is active against a wide range of aerobic and anaerobic Gram-negative and Gram-positive bacteria. The organisms that are susceptible to ocucycline ophthalmic ointment include Staphylococcus aureus, Streptococci including Streptococcus pneumonia, Escherichia coli, Neisseria species and Chylamydia trachomatis

Tetracycline hydrochloride is particularly useful for the treatment of infections caused by Haemophilus ducreyi, Enterobacter aerogenes, (formerly Aerobacter aerogenes), Shigella species, Mima species and Herellea species, Haemophilus influenza, Brucella and Vibrio cholera. It also inhibits the growth of Legionella pneumophila, Campylobacter jejuni,
Helicobacter pylori, Yersinia pestis, Yersinia enterocolita, Francisella tularensis and Pasteurella multocida and its activity against Actinomyces is particularly relevant.


Ocucycline® ophthalmic ointment is indicated for:

  • The treatment of superficial ocular infections involving the conjunctiva and or corne a due to susceptible organisms
  • The treatment of blepharitis
  • The prophylaxis of ophthalmia neonatorum


The use of Ocucycline® is contraindicated in patient with known hypersensitivity to Tetracycline group of antibiotics or any other ingredient of the formulation


As with other antibiotics preparations, use of Ocucycline® ophthalmic ointment may result in overgrowth of non-susceptible organisms, particularly fungi. Constant observation of the patient for this possibility is essential. If new infections due to non-susceptible organisms appear during therapy, appropriate measures should be taken.

Drug interactions

Since bacteriostatic medicines may interfere with the bactericidal action of penicillin, it is advisable to avoid using Tetracycline in conjunction with penicillins

Adverse reactions

The use of Tetracycline group of antibiotic is associated with hypersensitivity reactions including urticarial, angioneurotic edema, anaphylaxixs, anaphylactoid purpura and an exacerbation of systemic lupus erythematosus. Increased lacrimation, a transient stinging or burning sensation and foreign body sensation has been reported occasionally with ophthalmic products.

Dosage and administration

The usual recommended dose of Ocucycline® ophthalmic ointment is ¼ inch to ½ inch ribbon in the lower cul-de-sac, 4-6 times daily until the infection is cleared and healing is complete. This may take up to several weeks depending on the nature and severity of the infection

In blepharitis, scales and crusts should be removed before applying the medication.

Directions for use

1. To improve flow of the ointment, hold tube in hand for a few minutes to warm before use

2. When opening the ointment tube for the first time, squeeze out the first ¼ inch of the ointment and discard, as it may be too dry

3. While looking up, squeeze a small amount of the ointment, about ¼ inch to ½ inch, inside lower lid

4. Close eye gently and roll eyeball in all directions while eye is closed.

5. The closed eye lid may be rubbed very gently by a finger to distribute the ointment throughout the fornix


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