It is used in the treatment of diarrhoea and dysentery of amoebic, bacterial or mexedorgins. It is also used in amoebiasis (intestinal and extrea intestinal, giardiasis, trichomoniasis and anaerobic infections.
Dosage and regimen
As directed by physician or One tablet twice daily for 5 days in case of amoebiasis, trichomoniasis or diarrhea and dysentery due to mixed infections. Tablets should be taken one hour before or two hours after meals with a glass of water. Patients should be advised to drink fluid liberally. Antacids and sucralfate should not be taken concomitantly or within 2 hours of dosing.
Hypersensitivity to quinolone group of compounds or nitroimidazoles. It is also contraindicated to infants under one mounth of age, severe liver damage and in pregnancy.
Norfloxacin: some cases of nausea, headache, dizziness, fatigue, rash, abdominal pain, dyspepsia, somnolence, depression, insomnia, constipation, flatulence and heartburn have been reported. Less frequent reactions include dry mouth, diarrrhoea, fever, vomiting and erythema.
Tinidazole: metallic taste, nausea, vomiting, headache, urticarial, hypersensitivity and early leucopenia.
Precautions and warnings
Pregnancy: the drug should be avoided in pregnancy Nursing mothers: it is not recommended for use in nursing mothers
Paediatric use: it is not indicated for use in children
Impared renal function: if creatinine clearance is 10 to 30 ml/min the dose should be reduced to one tablet daily.