Vivian Gel 30gm

Vivian Gel 30gm (Diclofenac Gel)

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Vivian Gel 30gm (Diclofenac Gel)


  • Diclofenac Diethylamine BP 1.16% w/w
  • Eq. to Diclofenac Sodium 1.00% w/w
  • Linseed Oil BP 3.00%w/w
  • Methyl Salicylate BP 10.00% w/w
  • Menthol BP 5.00% w/w
  • Gel base Q.S.

Pharmacological class: Non-steroidal Anti-inflammatory and analgesic

Diclofenac is a non-steroidal anti-inflammatory (NSAID) and analgesic preparation designed for external application. Diclofenac is a potent non-steroidal anti-inflammatory drug with analgesic and antipyretic properties. It is also has uricosuric effect. Diclofenac inhibits cyclo-oxygenase activity with a reduction of production of prostaglandins in the tissue.

Linseed oil inhibits PGE2, leukotriene, histamine and bradykinin induces inflammation. The oil also inhibited arachidonic acid-induced inflammation, suggesting its capacity to inhibit both cyclooxygenase and lipooxygenase pathway of arachidonate metabolism.

Methyl Salicylate is applied topically as counter irritants for relief of pain associated with lumbago, sciatica, and rheumatic conditions.

Menthol, after topical application, causes a feeling of coolness due to stimulation of cold’receptors by inhibiting ca++ currents of neuronal membranes. It may also yield analgesic properties via kappa-opioid receptors agonism.


When Diclofenac Gel is applied locally the active substances are absorbed through the skin, determined by reference to the urinary excretion of Diclofenac and its hydroxylated metabolites. After topical administration of Diclofenac Gel to hand and knee joints Diclofenac can be measured in plasma, synovial tissue and synovial fluid.


Diclofenac Gel is used to relieve pain and reduce swelling in a number of painful conditions affecting the joints and muscles. It relieves rheumatic and muscular pain and reduces swelling and inflammation, e.g., in injuries involving the tendons, ligaments, muscles and joints. For the relief of sprains, strains or bruises, backache, tendinitis (e.g., tennis elbow), and for localized and mild arthritis.



Hypersensitivity to Diclofenac, acetylsalicylic acid, isopropanol propylene glycol or other components of the gel base.

Patients with or without chronic asthma in whom attacks of asthma, urticaria or acute rhinitis are precipitated by aspirin or other non-steroidal anti-inflammatory agents (NSAIDs).

The use in children and adolescents aged less than 14 years is contraindicated.

Special precautions and warnings

Diclofenac Gel should be applied only to intact skin and or open wounds. It should not come into contact with the eyes or mucous membranes.

Adverse effects

Occasional skin rash, itching and redness of the skin

Dosage and directions for use

Adults and Adolescents over 12 years of age: Depending on the size of the painful area to be treated, 2-4 g (a circular shaped mass approximately 2.0-2.5cm in diameter). Diclofenac Gel should be applied 3-4 times daily to the affected sites and gently rubbed-in. Duration of treatment depend on the indication and the patient’s response. It is advisable to review the treatment after 2 weeks.

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