Mebendazole is a benzimidazole carbamate derivative with broad spectrum anthelmintic activity. It is particularly active against gastro-intestinal nematodes (roundworms) and some cestodes (tapeworms). Activity against some larval stage and ova has also been demonstrated.
It appears to act by irreversible inhibition of glucose uptake in susceptible worms resulting in depletion of their energy stores, glycogen and adenosine triphosphate, resulting in their slow death.
Mebendazole is poorly absorbed from the gastro-intestinal tract and undergoes extensive first-pass elimination, being metabolized in the liver, eliminated in the bile as unchanged drug and metabolites and excreted in the faeces.
Only about 2% of a dose is excreted unchanged or as metabolites in the urine.
Infestation with any of the following and in mixed infections
- Threadworms (Pinworms, Enterobius vermicularis)
- Roundworms (Askaris lumbricoides)
- Whipworm (Trichuris trichiura)
- Hookworm (Ancylostoma duodenale, Necator americanus)
For adult and children over 2 years
- Threadworm infestations: one tablet to be chewed as a single dose or 5ml (one teaspoonful) of the suspension to be taken as a single dose, repeated if necessary after 2 to 3 weeks
- Roundworm, Hookworm, Whipworm and mixed infections: one tablet to be chewed twice daily or 5ml of the suspension to be taken twice daily for 3 consecutive days.
- Nausea, vomiting, abdominal pain, diarrhea and pruritus may occasionally occur.
- No serious reactions have been reported
- Use with caution in pregnancy
Children under two years