X-SONE Eye drops

X-SONE Eye drops

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X-SONE Eye drops (Dexamethasone Sodium Phosphate USP)

Dexamethasone is a synthetic adrenocorticosteroid with glucocorticoid activity. It is one of the most active glucocorticoids being about 25 to 30 times as potent as hydrocortisone. Unlike hydrocortisone, dexamethasone has little if any mineralocorticoid activity.

Dexamethasone has anti-inflammatory and immunosuppressant activity. Glucocorticoids prevent the development of the inflammatory response, i.e. redness, swelling, tenderness by inhibiting many of the initial events in an inflammatory response. They also inhibit capillary dilation and phagocytosis and appear to prevent the hypersensitivity responses which occur after antigen-antibody reactions.

Indications

X-SONE is used for the treatment of eye inflammations when the use of a corticosteroid is considered necessary.

Dosage

One or two drops topically in the conjunctival sac (s) every four hours, in severe disease, drops may be used hourly, being tapered to discontinuation as the inflammation subsides. Or use as directed by a physician.

Contraindications

This drug should not be used in presence of acute herpes simplex, tuberculosis of the eye, fungal disease of ocular or auricular structures, vaccinia, varicella and most viral diseases of the cornea and conjunctiva. It is contraindicated in perforated drum membrane and in patients sensitive to any of its components.

Precautions

Prolonged use may result in glaucoma, with damage to the optic nerve, defects in visual acuity and fields of vision. Prolonged use may suppress the host immune response and thus increase the hazard of secondary ocular infections. In those disease causing thinning of the cornea or sclera, perforations have been known to occur with the use of topical steroids. In acute purulent conditions of the eye, steroids may mask infection or enhance existing infection. If these products are used for 10 days or longer , intraocular pressure should be routinely monitored. Fungal infections of the cornea are particularly prone to develop coincidentally with long-term applications of steroids.

Before using X-SONE Eye drops, caution is also required in pregnancy or if you are breast feeding a baby.

Do not wear contact lenses whilst using X-SONE as the preservative may damage the lens.

Drug interactions

X-SONE may have the following interactions; barbiturates, carbamazepine, phenytoin or rifampin which may decrease dexamethasone drops’ effectiveness. There are a number of other possible interactions, ask your health care provider if dexamethasone drops may interact with other medicine that you take. Check with your health provider before you start, stop or change the dose of any medicine.

Side effects

Burning sensation, discomfort and itching, elevation of intra ocular pressure and possible development of glaucoma.

Direction for use

  • Tighten the cap on the nozzle.
  • The spike in the cap will pierce the tip of the vial.
  • Dispense drops with gentle pressure.
  • Replace the cap after every use.
Warning
  • If irritation persists or increase, discontinue the use and consult a physician
  • Do not touch the vial tip or other dispensing tip to any surface since this may contaminate the solution
  • Use the solution within four weeks after opening the vial.
Wash your hands well before use
  • Remove the outer cap
  • Tilt the head back and pull the lower lid of the eye down to form a pocket
  • Hold the container between the thumb and middle finger of the other hand, turn the container upside down near to the eye and try not to touch the eye
  • Apply enough pressure to the container to release one to two drops
  • Close the eye and keep it closed for one to two minutes
  • If you think you have missed the eye, then insert another drop
  • Repeat in the other eye if you have been instructed to use this preparation in both eyes
  • Replace the outer cap on the container, try not to touch the applicator tip with the fingers as you do so
  • Wash your hands.
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