XSONE-N eye/ear drops

X-SONE-N Eye/Ear drops

Share this
Advertisement

X-SONE-N Eye/Ear drops

Dexamethasone Phosphate 0.1%w/v

Neomycin sulphate USP 0.35%w/v

Dexamethasone is a potent synthetic glucocorticoid with little, if any, mineralocorticoid activity, and has a long duration of action. It suppresses inflammatory cell influx and inflammatory process.

Neomycin “irreversibly” binds to specific 30s-subunit proteins and 16s rRNA. Specifically Neomycin binds to four nucleotides of 16s rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16s rRNA of 30s sub-unit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and thus prevents or interferes with the protein synthesis in the bacteria.

Indications

Eye, treatment of inflammatory conditions of the anterior segment of the eye complicated by infection caused by organism sensitive to neomycin

Ear, treatment of inflammatory conditions of the external ear complicated by infection caused by organism sensitive to neomycin

Dosage

Eye:1-2 drops every 1-2 hrs or as prescribed by the physician

Ear:2-3 drops every 2-3 hrs or as prescribed by the physician

Contraindications

Prolonged use may result in glaucoma, damage of the optic nerve , defects in visual acuity and fields of vision, posterior sub-capsular pressure should be routinely monitored.

In those diseases causing thinning of the cornea, perforation has been known to have occurred with use of topical steroids.

As with other antibiotics containing preparations, prolonged use may result in overgrowth of non-susceptible organisms.

Caution is also required in pregnancy or if you are breast feeding a baby.

Advertisement

Do not wear soft contact lenses whilst using N-SONE-N as the preservative may damage the lens.

Drug interactions

X-SONE-N applied topically is not likely to produce significant drug interactions. Systemically, neomycin may enhance the anticoagulant effects of warfarin. Its ototoxicity may be increased by ethacrynic acid furosemide.

Concurrent use of barbiturates, phenytoin or rifampicin may enhance the metabolism and decrease the effect of corticosteroids

Side effects

Burning sensation, discomfort and itching. Elevation of intraocular pressure and possible development of glaucoma.

Direction for use

  • Tighten the cap on the nozzle.
  • The spike in the cap will pierce the tip of the vial.
  • Dispense drops with gentle pressure.
  • Replace the cap after every use.

Wash your hands well before use

  • Remove the outer cap
  • Tilt the head back and pull the lower lid of the eye down to form a pocket
  • Hold the container between the thumb and middle finger of the other hand, turn the container upside down near to the eye and try not to touch the eye
  • Apply enough pressure to the container to release one to two drops
  • Close the eye and keep it closed for one to two minutes
  • If you think you have missed the eye, then insert another drop
  • Repeat in the other eye if you have been instructed to use this preparation in both eyes
  • Replace the outer cap on the container, try not to touch the applicator tip with the fingers as you do so
  • Wash your hands.
Share this

Leave a Comment

Your email address will not be published. Required fields are marked *

error: Content is protected !!