ZENERGY® (Multivitamin oral solution)

ZENERGY® (Multivitamin oral solution)

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ZENERGY® (Multivitamin oral solution)

Each 5ml contains:

  • Vitamin A BP 3000IU
  • Colecalciferol BP 400IU
  • Thiamine Hydrochloride BP (Vitamin B1) 1.5 mg
  • Riboflavin as Riboflavin Sodium Phosphate BP (Vitamin B2) 0.5mg
  • Pyridoxine Hydrochloride BP (Vitamin B6) 1mg
  • Cyanocobalamin BP (Vitamin B12) 2mcg
  • Nicotinamide BP (Niacinamide) 10mg
  • Ascorbic acid BP (Vitamin C) 10mg
  • Flavored syrup base qs

Therapeutic category: A11B (Multivitamin plain)

The actions of ZENERGY® is a composite of the actions of the individual constituting vitamins.

Pharmacokinetics

All components of ZENERGY® are well absorbed from the gastrointestinal tract following oral administration. They are widely distributed to most body tissue. They cross the placenta and also appear in breast milk. Components of Vitamin B and C are not stored in the body to any appreciable extent and amounts of Vitamin B and C in excess of body needs are excreted in the urine either unchanged or as metabolites. Vitamin A esters are hydrolysed by pancreatic enzymes to retino. It is then absorbed and re-esterified.

Vitamin D3 is hydroxylated in liver and again hydroxylated in kidney. Its metabolites are excreted through faeces

Indications

Deficiency disease of Vitamin A, Vitamin D & Vitamin B group.

Also ZENERGY® may be taken as dietary supplements to meet the requirements for normal health to prevent deficiency diseases of the Vitamin A, Vitamin D and Vitamin B group which include Beriberi, Ariboflavinosis, Pellagra, poor night vision, Ricketts and Bleeding gums.

Contraindications

Hypersensitivity to any of the ingredients of ZENERGY®

Precaution

Excessive dose of Vitamin A should be avoided in pregnancy because of potential teratogenic effects

Lactating women should not take Vitamin D3 if possible, as this may lead to the development of hypercalcaemia in the infant.

Side effects

The normal dosage is well tolerated with no cases of adverse effects being reported.

Drug interactions

No very specific interactions are known.

Vitamin A: absorption of Vitamin A from the gastrointestinal tract may be reduced by the presence of neomycin, cholestyramine or liquid paraffin. It may also be impaired in cholestatic jaundice and fat malabsorption conditions.

Vitamin B6: reduces the effects of levodopa

Vitamin C: Large doses may cause diarrhoea and other gastrointestinal disturbances and are associated with the formation of renal calcium oxalate calculi. Vitamin C should be given with care to patients with hyperoxaluria. Tolerance may be induced with prolonged use of large doses.

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Vitamin D3: should not be administered to patients with hypercalcaemia, and be given with caution to infants, as they may have increased sensitivity to its effects. The effects of Vitamin D may be reduced in patients taking Isoniazid, Rifampicin, barbiturates or anticonvulasants.

Dosage

As directed by physician or

  • Children between 1-6 months: ½ to 1 teaspoonful daily (1 teaspoonful = 5ml)
  • Children between 6 months and 3 years: 1 ½ teaspoonful daily
  • Children above 3 years: 2 teaspoonful daily
  • Adults and adolescents: 1 teaspoonful 3 times a day

Overdosage

Individual vitamins have different symptoms.

Vitamin A: excessive amounts over long periods can lead to toxicity, known as hypervitaminosis A, characterized by fatigue, irritability and loss of weight, vomiting and other gastrointestinal disturbances, low grade fever, hepatosplenomegaly, skin changes, alopecia, dry hair, cracking and bleeding lips, anemia headache, hypercalcaemia, subcutaneous swelling and pains in bones and joints.

Symptoms of chronic toxicity in children may also include raised intracranial pressure and papilledema mimicking brain tumours, tinnitus visual disturbances which may be severe and painful swelling over the longbones.

Symptoms usually clear on withdrawal of vitamin A, but in children premature closure of the epiphyses of the long bones may result in arrested bone growth. Acute vitamin A intoxication may occur with very high doses and is characterised by sedation, dizzness, nausea and vomiting, erythema, pruritus and desquamation.

Vitamin B6: Long term administration of large doses of pyridoxine is associated with the development of severe peripheral neuropathies.

Vitamin D3: excessive intake of vitamin D3 leads to the development of hypercalcaemia which is characterised by anorexia, nausea, vomiting, constipation, abdominal pain, muscle weakness, mental disturbances, polydipsia, polyuria, bone pain, nephrocalcinosis, renal calculi and in severe cases cardiac arrhythmias and coma.

Treatment: if required should be treated symptomatically.

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